HEDS is part of the School of Health and Related Research (ScHARR) at the University of Sheffield. We undertake research, teaching, training and consultancy on all aspects of health related decision science, with a particular emphasis on health economics, HTA and evidence synthesis.

Thursday, 19 January 2017

November’s CEAs.....

Our quick search for CEA’s published in October uncovered 24 articles.   In the right-hand column of this blog is a CEA Archive, which includes our CEA search results by month.  Below are those in our areas of interest.
  • Mohiuddin S, Reeves B, Pufulete M, Maishman R, Dayer M, Macleod J, et al. Model-based cost-effectiveness analysis of B-type natriuretic peptide-guided care in patients with heart failure. BMJ open. 2016;6(12):e014010.
  • Shiffman D, Arellano AR, Caulfield MP, Louie JZ, Bare LA, Devlin JJ, et al. Use of low density lipoprotein particle number levels as an aid in statin treatment decisions for intermediate risk patients: a cost-effectiveness analysis. BMC cardiovascular disorders. 2016;16(1):251.
Image: MSH SOLO :: Week 21, Nov 01-07 by KayVee.INC

Wednesday, 18 January 2017

Birmingham HESG

There were 3 HEDS presentations at the recent HESG.  They were:
  • Aki Tsuchiya. An exploration of non-iterative time trade-off.
  • Matthew Franklin. Title: Self-reported and electronic resource-use data for trial-based economic evaluations: the current state of play in England and considerations for the future.
  • John Brazier. Own health valuation: are we asking the right question? 

And for trivia fans out there, for the first time at HESG, there was a session where the lead author (Luke Munford, Manchester), the discussant (Zoe Firth, Health Foundation), and the chair (Matthew Franklin, Sheffield) were all graduates from Sheffield’s MSc Economics and Health Economics.  We must be doing something write.

No, that wasn't a grammatical error.

Monday, 16 January 2017

Valuing Health MOOC

We are running our free online course on Valuing Health for the 4th time from the 30th January 2017.  Registration is available now. The course runs for 3 weeks (3 hours per week) and is introductory level. You can see the course page and watch the trailer here.

Image: health mart by christine592

Thursday, 12 January 2017

Hello Macau!

Over Christmas, the HEDS Blog had its first visitor from Macau....the 146th country to visit us.

Tuesday, 10 January 2017

Medtech Innovation Briefings (MIBs)…

… published since our last update in May are listed below.  The MIBs review relevant published evidence and the likely costs of new technologies. They are designed to be fast, flexible and responsive to the need for information on innovative technologies.  MIBs are commissioned by NHS England.  Further details are available here.
  • OCS Heart system for heart transplant
  • CytoSorb therapy for sepsis
  • Sternal Talon for sternal closure in cardiothoracic surgery
  • Impella 2.5 for haemodynamic support during high-risk percutaneous coronary interventions
  • UrgoStart for chronic wounds
  • Woundchek Protease Status for assessing elevated protease status in chronic wounds
  • Absorb Bioresorbable Vascular Scaffold for coronary artery disease
  • Needle-free arterial non-injectable connector
  • QuikRead go for C-reactive protein testing in primary care
  • VitalPAC for assessing vital signs of patients in hospital
  • FLEXISEQ for osteoarthritis
  • Alere Afinion CRP for C-reactive protein testing in primary care
  • Axxent electronic brachytherapy system for early stage breast cancer
  • OSNA for colon cancer staging
  • Alair bronchial thermoplasty system for adults with severe difficult to control asthma
  • Lutonix drug-coated balloon for peripheral arterial disease
  • QTUG for assessing falls risk and frailty
  • Stretta System for gastro-oesophageal reflux disease
  • S-Cath System for suprapubic catheterisation
  • Cellvizio confocal endomicroscopy system for characterising pancreatic cysts
  • Mobi-C for cervical disc replacement   
  • CareLink network service for remote monitoring of people with cardiac devices
  • Prolaris gene expression assay for assessing long-term risk of prostate cancer progression
  • Secca System for faecal incontinence   
  • LATITUDE NXT Patient Management System for monitoring cardiac devices at home
Image: Keep-Calm-and-demand-evidence by Azucena Santillan

Monday, 9 January 2017

Cochrane Collaboration Issue 12, 2016…

….is complete.  The website lists protocols and methodology papers as well, but we’ll just flag up the notable reviews; these being……
  • Gene therapy for haemophilia
  • Dressings for the prevention of surgical site infection
  • Exercise for haemophilia
  • Risperidone versus placebo for schizophrenia
  • Automated telephone communication systems for preventive healthcare and management of long-term conditions
  • Efavirenz or nevirapine in three-drug combination therapy with two nucleoside or nucleotide-reverse transcriptase inhibitors for initial treatment of HIV infection in antiretroviral-na├»ve individuals

Friday, 6 January 2017

Latest Publications from HEDS in December

Here are the latest publications from November, including those 'In Press' by HEDS colleagues and their collaborators. 

Image of the British Journal of Surgery
© British Journal of Surgery
       Duncan, R., Essat, M., Jones, G., Booth, A., Buckley Woods, H., Poku, E., Kaltenthaler, E., Keetharuth, A.D., Palfreyman, S., Michaels, J., 2016. Systematic review and qualitative evidence synthesis of patient-reported outcome measures for abdominal aortic aneurysm. Br. J. Surg. doi:10.1002/bjs.10407

       Fuller, G.W., Hernandez, M., Pallott, D., Lecky, F., Stevenson, M., Gabbe, B., n.d. Health State Preference Weights for the Glasgow Outcome Scale Following Traumatic Brain Injury: A Systematic Review and Mapping Study. Value Heal. doi:10.1016/j.jval.2016.09.2398

        Gray, A.J., Roobottom, C., Smith, J.E., Goodacre, S., Oatey, K., O’Brien, R., Storey, R.F., Na, L., Lewis, S.C., Thokala, P., Newby, D.E., 2016. The RAPID-CTCA trial (Rapid Assessment of Potential Ischaemic Heart Disease with CTCA) - a multicentre parallel-group randomised trial to compare early computerised tomography coronary angiography versus standard care in patients presenting with suspected or confirmed acute coronary syndrome: study protocol for a randomised controlled trial. Trials 17, 579. doi:10.1186/s13063-016-1717-2
Image of The Lancet journal
© The Lancet

Griffiths, P.D., Bradburn, M., Campbell, M.J., Cooper, C.L., Graham, R., Jarvis, D., Kilby, M.D., Mason, G., Mooney, C., Robson, S.C., Wailoo, A., group, M. collaborative, 2016. Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study. Lancet. doi:10.1016/S0140-6736(16)31723-8

Harnan, S.E., Essat, M., Gomersall, T., Tappenden, P., Pavord, I., Everard, M., Lawson, R., 2016. Exhaled nitric oxide in the
 diagnosis of asthma in adults: a systematic review. Clin. Exp. Allergy. doi:10.1111/cea.12867

Julious, S.A., Horspool, M.J., Davis, S., Bradburn, M., Norman, P., Shephard, N., Cooper, C.L., Smithson, W.H., Boote, J., Elphick, H., Loban, A., Franklin, M., Kua, W.S., May, R., Campbell, J., Williams, R., Rex, S., Bortolami, O., 2016. PLEASANT: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term - a cluster randomised controlled trial and economic evaluation. Heal. Technol Assess 20, 1–154. doi:10.3310/hta20930

Kearns, B., Chilcott, J., Whyte, S., Preston, L., Sadler, S., 2016. Cost-effectiveness of screening for ovarian cancer amongst postmenopausal women: a model-based economic evaluation. BMC Med 14, 200. doi:10.1186/s12916-016-0743-y

Image of Quality of Life Research Journal
© Quality of Life Research 
       Mukuria, C., Young, T., Keetharuth, A., Borghs, S., Brazier, J., 2016. Sensitivity and responsiveness of the EQ-5D-3L in patients with uncontrolled focal seizures: an analysis of Phase III trials of adjunctive brivaracetam. Qual Life Res. doi:10.1007/s11136-016-1483-3

       Uttley, L., Whyte, S., Gomersall, T., Ren, S., Wong, R., Chambers, D., Tappenden, P., 2016. Degarelix for Treating Advanced Hormone-Dependent Prostate Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Pharmacoeconomics. doi:10.1007/s40273-016-0481-1

Thursday, 5 January 2017

A new year, a new job?

We are currently advertising for a Research Associate/Fellow in Health Economics.  The post will be focused on applied cost-effectiveness analysis and methods development as part of the NICE Decision Support Unit, the ScHARR Technology Appraisal Group, and other project-specific grants within the work programme of HEDS.

Image: New Years 2017 by maf04
Applicants should have research experience in health economics, specifically relating to either cost-effectiveness analysis of patient level data or decision analytic modelling. You should have a Masters Degree or equivalent in a numerate subject, for example, mathematics, operational research, statistics or economics. A PhD in a related subject is desirable.

This post is full-time and for a fixed-term period of 3 years. The closing date for applications is 23rd January 2017.  Further details can be found here.

Tuesday, 3 January 2017

Simulation Short Course…booking deadline approaching

This 3 day course runs from Tuesday, 24th - Thursday, 26th January 2017.  The course provides an in-depth review of individual-level simulation rationale, techniques and methodologies with a particular focus on discrete event simulation and its practical application to inform healthcare decision making. From the fundamentals of a basic model the course will progress to modelling complex systems, verification and interpreting output, as well as exploring alternative software options.

The course will be taught by Dr Hazel Pilgrim, Professor Matt Stevenson and Dr Sarah Davis.

The booking deadline is Sunday, 8th January 2017.  Further information can bee found here.  For full details of all ScHARR short courses can be found here.

Image: Happy New Year by MoM Fotografie

Thursday, 22 December 2016

HEDS in the media in 2016

HEDS’ research and collaborations receive a lot of coverage in the press and across social and traditional media platforms. We have looked back over the past year to pick out a few highlights from some of our work that received coverage and how far it reached across social media and other notable web citations.

According to Altmetric.com our research and collaborations with external partners recieved 4,756 mentions in 2016 with a couple of weeks still to go. Altmetric tracks all of our research outputs, so many of the new mentions were also for research pre-2016, but we will take a look at a few of the notable highlights from this year’s outputs.

Image of HEDS Altmetric data for 2016
HEDS Altmetric data for 2016

Of the mentions, 105 were news items, our research was cited in 24 policy documents and 17 Wikipedia citations. On social media our research was mentioned in 4,391 Tweets, 121 Facebook Shares and 17 Google+ shares. whilst it was linked and featured on 72 blog posts, mentioned on open peer review and ranked on Reddit on a handful of occasions. Our research and collaborations were Tweeted about in 34 different countries with the United Kingdom, United States, Australia, Canada and Spain being the most prominent communicators.

It is important to say that this is the research mentions we are aware of, as Altmetric can only track research that has some kind of digital object identifier - such as a PubMed ID - in the communications.

Our Sheffield Alcohol Research Group continued their strong research output alongside collaborators again. ‘Are recent attempts to quit smoking associated with reduced drinking in England? A cross-sectional population survey’ received a lot of attention with 34 mentions in the news media. Top Sante, Metro News, NHS Choices, Google News alongside many regional news publications ran stories based on the conclusions from the research.

Dr Andrew Booth’s paper ‘Searching for qualitative research for inclusion in systematic reviews: a structured methodological review’ received a lot of traction thanks to 216 Tweets as well as a mention on the Evidently Cochrane Blog.
Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review was mentioned by a dozen news outlets. The research was featured in news by Science Daily, Genomeweb, Medical News Today, Health Medicine Network and Health Canal among others. The work was done by Lesley Utley, Helen Buckley Woods and Susan Harnan with collaborators based at institutions in the Midlands.